

Am J Physiol Cell Physiol 281:C700–C708Ĭzirjak G, Toth ZE, Enyedi P (2004) The two-pore domain K + channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.

J Neurosci 31:1375–1385Ĭzirjak G, Petheo GL, Spat A, Enyedi P (2001) Inhibition of TASK-1 potassium channel by phospholipase C. Am J Physiol Gastrointest Liver Physiol 284:G8–G14Ĭadaveira-Mosquera A, Ribeiro SJ, Reboreda A, Pérez M, Lamas JA (2011) Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons. Integration of afferent signaling from the viscera by the nodose ganglia. Br J Pharmacol 70:593–608īrowning KN, Mendelowitz D (2003) Musings on the wanderer: what's new in our understanding of vago-vagal reflexes?: II. Life Sci 60:1137–1144īrown DA, Constanti A (1980) Intracellular observations on the effects of muscarinic agonists on rat sympathetic neurones. J Mol Biol 215:403–410īrown DA, Abogadie FC, Allen TG, Buckley NJ, Caulfield MP, Delmas P, Haley JE, Lamas JA, Selyanko AA (1997) Muscarinic mechanisms in nerve cells. Our results strongly suggest that TRESK and TREK channels are important modulators of the sensorial and motor information flowing through the autonomic nervous system, probably exerting a strong influence on vagal reflexes.Īltschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. As the level of TRESK mRNA expression was not statistically different between the ganglia analysed, the distinct expression of TREK-1 and TREK-2 subunits was the main difference observed between these structures. Moreover, cell-attached single-channel recordings showed a major contribution of TRESK and TREK-1 channels in mNG. Similarly, the TRESK and TREK-1 subunits were the most strongly expressed in sensorial mNG neurons, while TASK-1 and TASK-2 mRNAs were moderately expressed, and fewer TREK-2 and TRAAK transcripts were detected (TRESK ≈ TREK-1 > TASK-1 ≈ TASK-2 > TREK-2 > TRAAK). Motor mSCG neurons strongly expressed mRNA transcripts for TRESK and TREK-2 subunits, whereas TASK-1 and TASK-2 subunits were only moderately expressed, with only few or very few transcripts for TREK-1 and TRAAK (TRESK ≈ TREK-2 > TASK-2 ≈ TASK-1 > TREK-1 > TRAAK).

We observed strong mRNA expression of members of the TRESK and TREK subfamilies in both the mouse superior cervical ganglion (mSCG) and the mouse nodose ganglion (mNG). We demonstrate that these channels are also expressed in the autonomic nervous system where they might be important modulators of neuronal excitability. Several types of neurons within the central and peripheral somatic nervous system express two-pore-domain potassium (K2P) channels, providing them with resting potassium conductances.
